We asked few days back –
If you want to measure GC of a genome of size 300 million bp, and computing is so expensive that checking each nucleotide costs $3, what is the most logical solution?
The question can be slightly modified to make it more presentable to an experimentalist.
Suppose you want to estimate GC content of a 300MB large genome, and sequencing the full genome is very expensive. What will you do?
Every scientist we posed the question to suggested that we measure GC content of part of the genome. Most agreed that as long as we take many small fragments from all over the genome, it is enough to sequence or analyze only 1% of the genome. So, essentially, we can estimate the GC content of a 300 Mb genome by measuring GC content for many small pieces of the genome together, whose combined length is 3Mb.
When it comes to election, every one of those American scientists agreed that all eligible persons of this country of 300 million should vote, and ‘every vote counts’. Is that not odd?